GABRQ
Summary: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. [provided by RefSeq, Jul 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| gamma-aminobutyric acid type A receptor theta subunit | MIM:300349 | Ensembl:ENSG00000268089 | HGNC:HGNC:14454 | PA28504 | Xq28 |
GO terms in GABRQ
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0004890 | GABA-A receptor activity |
| MF | IBA | GO:0005230 | extracellular ligand-gated ion channel activity |
| MF | IEA | GO:0005230 | extracellular ligand-gated ion channel activity |
| MF | IEA | GO:0005254 | chloride channel activity |
| MF | TAS | GO:0005326 | neurotransmitter transporter activity |
| BP | IEA | GO:0006836 | neurotransmitter transport |
| BP | IBA | GO:0007165 | signal transduction |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0034220 | ion transmembrane transport |
| BP | IBA | GO:0042391 | regulation of membrane potential |
| BP | IBA | GO:0050877 | nervous system process |
| BP | IEA | GO:1902476 | chloride transmembrane transport |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0034707 | chloride channel complex |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IBA | GO:0045202 | synapse |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | IBA | GO:1902711 | GABA-A receptor complex |
Gene expression in normal tissue: GABRQ
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GABRQ
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| kegg | hsa05033 | Nicotine addiction - Homo sapiens (human) |
| wikipathways | WP4159 | GABA receptor Signaling |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-977441 | GABA A receptor activation |
| reactome | R-HSA-977443 | GABA receptor activation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GABRQ
CLASSFICATION
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