Summary: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. [provided by RefSeq, Jul 2017].

gamma-aminobutyric acid type A receptor theta subunitMIM:300349Ensembl:ENSG00000268089HGNC:HGNC:14454PA28504Xq28

GO terms in GABRQ

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004888transmembrane signaling receptor activity
MFIBAGO:0004890GABA-A receptor activity
MFIBAGO:0005230extracellular ligand-gated ion channel activity
MFIEAGO:0005230extracellular ligand-gated ion channel activity
MFIEAGO:0005254chloride channel activity
MFTASGO:0005326neurotransmitter transporter activity
BPIEAGO:0006836neurotransmitter transport
BPIBAGO:0007165signal transduction
BPTASGO:0007165signal transduction
BPIBAGO:0007268chemical synaptic transmission
BPIBAGO:0034220ion transmembrane transport
BPIBAGO:0042391regulation of membrane potential
BPIBAGO:0050877nervous system process
BPIEAGO:1902476chloride transmembrane transport
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0030054cell junction
CCIEAGO:0034707chloride channel complex
CCIBAGO:0043005neuron projection
CCIDAGO:0043235receptor complex
CCIEAGO:0045211postsynaptic membrane
CCIBAGO:1902711GABA-A receptor complex

Gene expression in normal tissue: GABRQ

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GABRQ

DatabasePathway IDPathway Des.
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
kegghsa05033Nicotine addiction - Homo sapiens (human)
wikipathwaysWP4159GABA receptor Signaling
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-977441GABA A receptor activation
reactomeR-HSA-977443GABA receptor activation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GABRQ