APOBR
Summary: Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:605220 Ensembl IDEnsembl:ENSG00000184730 HGNC IDHGNC:HGNC:24087 PHARMGKB IDPA166048957 Map Location16p12.1 | |||||
GO terms in APOBR
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006641 | triglyceride metabolic process |
| BP | IEA | GO:0006869 | lipid transport |
| BP | IEA | GO:0008203 | cholesterol metabolic process |
| BP | TAS | GO:0034447 | very-low-density lipoprotein particle clearance |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: APOBR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APOBR
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-8964043 | Plasma lipoprotein clearance |
| reactome | R-HSA-8964046 | VLDL clearance |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APOBR
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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