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APOBR

Summary: Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
apolipoprotein B receptor	MIM:605220	Ensembl:ENSG00000184730	HGNC:HGNC:24087	PA166048957	16p12.1

GO terms in APOBR

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0006641	triglyceride metabolic process
BP	IEA	GO:0006869	lipid transport
BP	IEA	GO:0008203	cholesterol metabolic process
BP	TAS	GO:0034447	very-low-density lipoprotein particle clearance
CC	TAS	GO:0005886	plasma membrane
CC	HDA	GO:0016020	membrane
CC	IEA	GO:0034361	very-low-density lipoprotein particle
CC	IEA	GO:0034362	low-density lipoprotein particle
CC	IEA	GO:0042627	chylomicron
MF	IBA	GO:0030229	very-low-density lipoprotein particle receptor activity

Gene expression in normal tissue: APOBR

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in APOBR

Database	Pathway ID	Pathway Des.
reactome	R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance
reactome	R-HSA-382551	Transport of small molecules
reactome	R-HSA-8964043	Plasma lipoprotein clearance
reactome	R-HSA-8964046	VLDL clearance

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in APOBR

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.