BAIAP2L1


Summary: This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BAI1 associated protein 2 like 1MIM:611877Ensembl:ENSG00000006453HGNC:HGNC:21649PA1426725627q21.3-q22.1

GO terms in BAIAP2L1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005654nucleoplasm
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCHDAGO:0005913cell-cell adherens junction
CCIBAGO:0015629actin cytoskeleton
CCIDAGO:0015629actin cytoskeleton
CCHDAGO:0070062extracellular exosome
BPIEAGO:0007009plasma membrane organization
BPIDAGO:0009617response to bacterium
BPIBAGO:0030838positive regulation of actin filament polymerization
BPIDAGO:0030838positive regulation of actin filament polymerization
BPIEAGO:0046626regulation of insulin receptor signaling pathway
BPIBAGO:0051017actin filament bundle assembly
BPIBAGO:0051764actin crosslink formation
BPIEAGO:0098609cell-cell adhesion
BPIBAGO:2000251positive regulation of actin cytoskeleton reorganization
BPIMPGO:2000251positive regulation of actin cytoskeleton reorganization
MFIEAGO:0003779actin binding
MFIPIGO:0005515protein binding
MFIDAGO:0070064proline-rich region binding
MFHDAGO:0098641cadherin binding involved in cell-cell adhesion

Gene expression in normal tissue: BAIAP2L1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BAIAP2L1


DatabasePathway IDPathway Des.
netpathPathway_EGFR1EGFR1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BAIAP2L1

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