Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008].

mitogen-activated protein kinase 9MIM:602896Ensembl:ENSG00000050748HGNC:HGNC:6886PA306305q35.3

GO terms in MAPK9

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004705JUN kinase activity
MFIBAGO:0004707MAP kinase activity
MFIEAGO:0004712protein serine/threonine/tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0008134transcription factor binding
BPIMPGO:0006468protein phosphorylation
BPIDAGO:0007254JNK cascade
BPTASGO:0007254JNK cascade
BPIEAGO:0007258JUN phosphorylation
BPIBAGO:0009612response to mechanical stimulus
BPIBAGO:0010468regulation of gene expression
BPIMPGO:0010628positive regulation of gene expression
BPIMPGO:0010744positive regulation of macrophage derived foam cell differentiation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIEAGO:0031398positive regulation of protein ubiquitination
BPIMPGO:0034614cellular response to reactive oxygen species
BPIBAGO:0035556intracellular signal transduction
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPISSGO:0042752regulation of circadian rhythm
BPIBAGO:0043065positive regulation of apoptotic process
BPIEAGO:0048511rhythmic process
BPIBAGO:0048666neuron development
BPIEAGO:0061833protein localization to tricellular tight junction
BPIMPGO:0071276cellular response to cadmium ion
BPIBAGO:0071310cellular response to organic substance
BPIEAGO:0071803positive regulation of podosome assembly
BPIEAGO:1901485positive regulation of transcription factor catabolic process
BPIEAGO:2001235positive regulation of apoptotic signaling pathway
CCIBAGO:0043005neuron projection

Gene expression in normal tissue: MAPK9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAPK9

DatabasePathway IDPathway Des.
biocartamapkpathwaymapkinase signaling pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2871796FCERI mediated MAPK activation
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450321JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
reactomeR-HSA-450341Activation of the AP-1 family of transcription factors
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2516ATM Signaling Pathway
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3874Canonical and Non-Canonical TGF-B signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3927BMP Signaling Pathway in Eyelid Development
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins
wikipathwaysWP4150Wnt Signaling in Kidney Disease
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4223Ras Signaling
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP560TGF-beta Receptor Signaling
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
wikipathwaysWP712Estrogen signaling pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
pharmgkbPA2032VEGF Signaling Pathway
pidatf2_pathwayATF-2 transcription factor network
pidcd40_pathwayCD40/CD40L signaling
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcdc42_pathwayCDC42 signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidfaspathwayFAS (CD95) signaling pathway
pidfoxopathwayFoxO family signaling
pidglypican_3pathwayGlypican 3 network
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidil2_1pathwayIL2-mediated signaling events
pidnephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidp53regulationpathwayp53 pathway
pidp75ntrpathwayp75(NTR)-mediated signaling
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidrac1_pathwayRAC1 signaling pathway
pidrapid_gr_pathwayRapid glucocorticoid signaling
pidrb_1pathwayRegulation of retinoblastoma protein
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidwnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPK9