KLK6


Summary: This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
kallikrein related peptidase 6MIM:602652Ensembl:ENSG00000167755HGNC:HGNC:6367PA3015619q13.41

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in KLK6


Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0007417central nervous system development
BPNASGO:0009611response to wounding
BPIEAGO:0010975regulation of neuron projection development
BPNASGO:0016540protein autoprocessing
BPNASGO:0030574collagen catabolic process
BPNASGO:0042246tissue regeneration
BPNASGO:0042445hormone metabolic process
BPNASGO:0042552myelination
BPNASGO:0042982amyloid precursor protein metabolic process
BPNASGO:0045595regulation of cell differentiation
BPIDAGO:0045745positive regulation of G-protein coupled receptor protein signaling pathway
BPIMPGO:0070997neuron death
CCIDAGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCIEAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCIEAGO:0005783endoplasmic reticulum
CCIBAGO:0030141secretory granule
MFIDAGO:0004252serine-type endopeptidase activity
MFNASGO:0004252serine-type endopeptidase activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: KLK6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KLK6


DatabasePathway IDPathway Des.
pidalphasynuclein_pathwayAlpha-synuclein signaling
wikipathwaysWP2877Vitamin D Receptor Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLK6

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