KLK6
Summary: This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602652 Ensembl IDEnsembl:ENSG00000167755 HGNC IDHGNC:HGNC:6367 PHARMGKB IDPA30156 Map Location19q13.41 | |||||
GO terms in KLK6
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0007417 | central nervous system development |
| BP | NAS | GO:0009611 | response to wounding |
| BP | IEA | GO:0010975 | regulation of neuron projection development |
| BP | NAS | GO:0016540 | protein autoprocessing |
| BP | NAS | GO:0030574 | collagen catabolic process |
| BP | NAS | GO:0042246 | tissue regeneration |
Gene expression in normal tissue: KLK6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLK6
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KLK6
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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