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KCNK12

Summary: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namepotassium two pore domain channel subfamily K member 12 OMIM IDMIM:607366 Ensembl IDEnsembl:ENSG00000184261 HGNC IDHGNC:HGNC:6274 PHARMGKB IDPA30054 Map Location2p16.3

Gene Categories:

ION CHANNEL TRANSPORTER DRUGGABLE GENOME

GO terms in KCNK12

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0005244	voltage-gated ion channel activity
MF	IBA	GO:0022841	potassium ion leak channel activity
CC	IBA	GO:0005887	integral component of plasma membrane
BP	IBA	GO:0030322	stabilization of membrane potential
BP	IEA	GO:0034765	regulation of ion transmembrane transport
BP	IBA	GO:0071805	potassium ion transmembrane transport

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Gene expression in normal tissue: KCNK12

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNK12

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-397014	Muscle contraction
reactome	R-HSA-5576886	Phase 4 - resting membrane potential
reactome	R-HSA-5576891	Cardiac conduction

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNK12

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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