CELF4
Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CUGBP Elav-like family member 4 | MIM:612679 | Ensembl:ENSG00000101489 | HGNC:HGNC:14015 | PA25428 | 18q12.2 |
GO terms in CELF4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| BP | IDA | GO:0000380 | alternative mRNA splicing, via spliceosome |
| BP | IBA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | IDA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | IBA | GO:0006376 | mRNA splice site selection |
| BP | IEA | GO:0006376 | mRNA splice site selection |
| BP | NAS | GO:0007281 | germ cell development |
| BP | NAS | GO:0009792 | embryo development ending in birth or egg hatching |
| BP | IEA | GO:0017148 | negative regulation of translation |
| BP | IEA | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| BP | IDA | GO:0048026 | positive regulation of mRNA splicing, via spliceosome |
| BP | IEA | GO:0090394 | negative regulation of excitatory postsynaptic potential |
| BP | IEA | GO:1902866 | regulation of retina development in camera-type eye |
| MF | NAS | GO:0000900 | translation repressor activity, mRNA regulatory element binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003729 | mRNA binding |
| MF | IEA | GO:0003729 | mRNA binding |
| MF | IDA | GO:0036002 | pre-mRNA binding |
| MF | ISS | GO:0042835 | BRE binding |
Gene expression in normal tissue: CELF4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CELF4
CLASSFICATION
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