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PRDM8

Summary: This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
PR/SET domain 8	MIM:616639	Ensembl:ENSG00000152784	HGNC:HGNC:13993	PA33720	4q21.21

Gene Categories:

METHYL TRANSFERASE

GO terms in PRDM8

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IEA	GO:0006357	regulation of transcription by RNA polymerase II
BP	IBA	GO:0014003	oligodendrocyte development
BP	IEA	GO:0032259	methylation
CC	IDA	GO:0005634	nucleus
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IEA	GO:0003677	DNA binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008168	methyltransferase activity
MF	IEA	GO:0046872	metal ion binding

Gene expression in normal tissue: PRDM8

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRDM8

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRDM8

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DATATYPES

CLASSFICATION

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