CTNNBIP1

Summary: The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecatenin beta interacting protein 1
OMIM IDMIM:607758
Ensembl IDEnsembl:ENSG00000178585
HGNC IDHGNC:HGNC:16913
PHARMGKB IDPA27014
Map Location1p36.22

GO terms in CTNNBIP1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005737 cytoplasm
CC IBA GO:0005829 cytosol
CC IDA GO:0005829 cytosol
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Gene expression in normal tissue: CTNNBIP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CTNNBIP1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-195721 Signaling by WNT
reactome R-HSA-201681 TCF dependent signaling in response to WNT
reactome R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
wikipathways WP428 Wnt Signaling Pathway
kegg hsa04310 Wnt signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTNNBIP1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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