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AKR1B10

Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namealdo-keto reductase family 1 member B10 OMIM IDMIM:604707 Ensembl IDEnsembl:ENSG00000198074 HGNC IDHGNC:HGNC:382 PHARMGKB IDPA24676 Map Location7q33

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DRUGGABLE GENOME

GO terms in AKR1B10

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0001523	retinoid metabolic process
BP	IDA	GO:0016488	farnesol catabolic process
BP	IMP	GO:0044597	daunorubicin metabolic process
BP	IMP	GO:0044598	doxorubicin metabolic process
BP	IEA	GO:0055114	oxidation-reduction process
CC	IEA	GO:0005576	extracellular region

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Gene expression in normal tissue: AKR1B10

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AKR1B10

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Database	Pathway ID	Pathway Des.
wikipathways	WP702	Metapathway biotransformation Phase I and II
kegg	hsa00040	Pentose and glucuronate interconversions - Homo sapiens (human)
kegg	hsa00051	Fructose and mannose metabolism - Homo sapiens (human)
kegg	hsa00052	Galactose metabolism - Homo sapiens (human)
kegg	hsa00561	Glycerolipid metabolism - Homo sapiens (human)
kegg	hsa00790	Folate biosynthesis - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD68	Paclitaxel	3
iGMDRD309	17AAG	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKR1B10

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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