PDXP
Summary: Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609246 Ensembl IDEnsembl:ENSG00000241360 HGNC IDHGNC:HGNC:30259 PHARMGKB IDPA134882132 Map Location22q13.1 | |||||
GO terms in PDXP
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0000287 | magnesium ion binding |
| MF | IEA | GO:0004647 | phosphoserine phosphatase activity |
| MF | IBA | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IDA | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016791 | phosphatase activity |
Gene expression in normal tissue: PDXP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDXP
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PLPSAL-PWY | pyridoxal 5,-phosphate salvage |
| kegg | hsa00750 | Vitamin B6 metabolism - Homo sapiens (human) |
| smpdb | SMP00017 | Vitamin B6 Metabolism |
| smpdb | SMP00503 | Hypophosphatasia |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDXP
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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