PDXP


Summary: Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
pyridoxal phosphataseMIM:609246Ensembl:ENSG00000241360HGNC:HGNC:30259PA13488213222q13.1

GO terms in PDXP


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0000287magnesium ion binding
MFIEAGO:0004647phosphoserine phosphatase activity
MFIBAGO:0004721phosphoprotein phosphatase activity
MFIDAGO:0004721phosphoprotein phosphatase activity
MFIPIGO:0005515protein binding
MFIBAGO:0016791phosphatase activity
MFIDAGO:0031072heat shock protein binding
MFISSGO:0033883pyridoxal phosphatase activity
MFIEAGO:0042803protein homodimerization activity
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIEAGO:0005911cell-cell junction
CCIDAGO:0015629actin cytoskeleton
CCIDAGO:0030027lamellipodium
CCIDAGO:0030496midbody
CCIEAGO:0031258lamellipodium membrane
CCIDAGO:0032154cleavage furrow
CCIDAGO:0032587ruffle membrane
CCIDAGO:0070938contractile ring
BPIBAGO:0006470protein dephosphorylation
BPIDAGO:0006470protein dephosphorylation
BPIMPGO:0007088regulation of mitotic nuclear division
BPIBAGO:0016311dephosphorylation
BPIMPGO:0030836positive regulation of actin filament depolymerization
BPIDAGO:0031247actin rod assembly
BPIMPGO:0031247actin rod assembly
BPISSGO:0032361pyridoxal phosphate catabolic process
BPIMPGO:0032465regulation of cytokinesis
BPIDAGO:0071318cellular response to ATP

Gene expression in normal tissue: PDXP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDXP


DatabasePathway IDPathway Des.
humancycPLPSAL-PWYpyridoxal 5,-phosphate salvage
kegghsa00750Vitamin B6 metabolism - Homo sapiens (human)
smpdbSMP00017Vitamin B6 Metabolism
smpdbSMP00503Hypophosphatasia

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDXP

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