PDXP
Summary: Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pyridoxal phosphatase | MIM:609246 | Ensembl:ENSG00000241360 | HGNC:HGNC:30259 | PA134882132 | 22q13.1 |
GO terms in PDXP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0000287 | magnesium ion binding |
| MF | IEA | GO:0004647 | phosphoserine phosphatase activity |
| MF | IBA | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IDA | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016791 | phosphatase activity |
| MF | IDA | GO:0031072 | heat shock protein binding |
| MF | ISS | GO:0033883 | pyridoxal phosphatase activity |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0030496 | midbody |
| CC | IEA | GO:0031258 | lamellipodium membrane |
| CC | IDA | GO:0032154 | cleavage furrow |
| CC | IDA | GO:0032587 | ruffle membrane |
| CC | IDA | GO:0070938 | contractile ring |
| BP | IBA | GO:0006470 | protein dephosphorylation |
| BP | IDA | GO:0006470 | protein dephosphorylation |
| BP | IMP | GO:0007088 | regulation of mitotic nuclear division |
| BP | IBA | GO:0016311 | dephosphorylation |
| BP | IMP | GO:0030836 | positive regulation of actin filament depolymerization |
| BP | IDA | GO:0031247 | actin rod assembly |
| BP | IMP | GO:0031247 | actin rod assembly |
| BP | ISS | GO:0032361 | pyridoxal phosphate catabolic process |
| BP | IMP | GO:0032465 | regulation of cytokinesis |
| BP | IDA | GO:0071318 | cellular response to ATP |
Gene expression in normal tissue: PDXP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDXP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PLPSAL-PWY | pyridoxal 5,-phosphate salvage |
| kegg | hsa00750 | Vitamin B6 metabolism - Homo sapiens (human) |
| smpdb | SMP00017 | Vitamin B6 Metabolism |
| smpdb | SMP00503 | Hypophosphatasia |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDXP
CLASSFICATION
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