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AGTRAP

Summary: This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
angiotensin II receptor associated protein	MIM:608729	Ensembl:ENSG00000177674	HGNC:HGNC:13539	PA38363	1p36.22

Gene Categories:

G PROTEIN COUPLED RECEPTOR

GO terms in AGTRAP

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0004945	angiotensin type II receptor activity
MF	IPI	GO:0005515	protein binding
CC	IEA	GO:0000139	Golgi membrane
CC	IDA	GO:0005654	nucleoplasm
CC	IEA	GO:0005789	endoplasmic reticulum membrane
CC	IDA	GO:0005829	cytosol
CC	IEA	GO:0005886	plasma membrane
CC	IEA	GO:0005938	cell cortex
CC	IEA	GO:0016021	integral component of membrane
CC	IEA	GO:0030659	cytoplasmic vesicle membrane
CC	IDA	GO:0043231	intracellular membrane-bounded organelle
BP	IEA	GO:0001666	response to hypoxia
BP	IEA	GO:0008217	regulation of blood pressure
BP	IEA	GO:0038166	angiotensin-activated signaling pathway

Gene expression in normal tissue: AGTRAP

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AGTRAP

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1643685	Disease
reactome	R-HSA-5663202	Diseases of signal transduction
reactome	R-HSA-6802952	Signaling by BRAF and RAF fusions
reactome	R-HSA-6802957	Oncogenic MAPK signaling

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AGTRAP

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DATATYPES

CLASSFICATION

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