AGTRAP

Summary: This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameangiotensin II receptor associated protein
OMIM IDMIM:608729
Ensembl IDEnsembl:ENSG00000177674
HGNC IDHGNC:HGNC:13539
PHARMGKB IDPA38363
Map Location1p36.22

GO terms in AGTRAP


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0004945 angiotensin type II receptor activity
MF IPI GO:0005515 protein binding
CC IEA GO:0000139 Golgi membrane
CC IDA GO:0005654 nucleoplasm
CC IEA GO:0005789 endoplasmic reticulum membrane
CC IDA GO:0005829 cytosol
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Gene expression in normal tissue: AGTRAP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in AGTRAP


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1643685 Disease
reactome R-HSA-5663202 Diseases of signal transduction
reactome R-HSA-6802952 Signaling by BRAF and RAF fusions
reactome R-HSA-6802957 Oncogenic MAPK signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AGTRAP

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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