RTN4
Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| reticulon 4 | MIM:604475 | Ensembl:ENSG00000115310 | HGNC:HGNC:14085 | PA34883 | 2p16.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in RTN4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | HDA | GO:0045296 | cadherin binding |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | NAS | GO:0006915 | apoptotic process |
| BP | IBA | GO:0007409 | axonogenesis |
| BP | IBA | GO:0007413 | axonal fasciculation |
| BP | ISS | GO:0007413 | axonal fasciculation |
| BP | IMP | GO:0010634 | positive regulation of epithelial cell migration |
| BP | ISS | GO:0021801 | cerebral cortex radial glia guided migration |
| BP | IMP | GO:0030308 | negative regulation of cell growth |
| BP | IDA | GO:0030517 | negative regulation of axon extension |
| BP | IMP | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation |
| BP | NAS | GO:0042981 | regulation of apoptotic process |
| BP | IEA | GO:0048694 | positive regulation of collateral sprouting of injured axon |
| BP | TAS | GO:0050771 | negative regulation of axonogenesis |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IMP | GO:0051292 | nuclear pore complex assembly |
| BP | IMP | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0060317 | cardiac epithelial to mesenchymal transition |
| BP | HEP | GO:0071277 | cellular response to calcium ion |
| BP | IMP | GO:0071786 | endoplasmic reticulum tubular network organization |
| BP | IDA | GO:0071787 | endoplasmic reticulum tubular network formation |
| BP | IEA | GO:1903860 | negative regulation of dendrite extension |
| BP | IDA | GO:1905552 | positive regulation of protein localization to endoplasmic reticulum |
| BP | IMP | GO:1905580 | positive regulation of ERBB3 signaling pathway |
| BP | IEA | GO:1905943 | negative regulation of formation of growth cone in injured axon |
| BP | IMP | GO:1990809 | endoplasmic reticulum tubular network membrane organization |
| BP | ISS | GO:2000172 | regulation of branching morphogenesis of a nerve |
| CC | IMP | GO:0005622 | intracellular |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | HDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | NAS | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IDA | GO:0030176 | integral component of endoplasmic reticulum membrane |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0044294 | dendritic growth cone |
| CC | IDA | GO:0071782 | endoplasmic reticulum tubular network |
| CC | IDA | GO:0098826 | endoplasmic reticulum tubular network membrane |
Gene expression in normal tissue: RTN4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RTN4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-193634 | Axonal growth inhibition (RHOA activation) |
| reactome | R-HSA-193697 | p75NTR regulates axonogenesis |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP2431 | Spinal Cord Injury |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RTN4
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.