ZMIZ1
Summary: This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| zinc finger MIZ-type containing 1 | MIM:607159 | Ensembl:ENSG00000108175 | HGNC:HGNC:16493 | PA162409804 | 10q22.3 |
GO terms in ZMIZ1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0008270 | zinc ion binding |
| BP | IEA | GO:0001570 | vasculogenesis |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0003007 | heart morphogenesis |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0007296 | vitellogenesis |
| BP | IEA | GO:0007569 | cell aging |
| BP | ISS | GO:0045582 | positive regulation of T cell differentiation |
| BP | ISS | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IEA | GO:0048589 | developmental growth |
| BP | IEA | GO:0048844 | artery morphogenesis |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: ZMIZ1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZMIZ1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZMIZ1
CLASSFICATION
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