Summary: The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011].

VANGL planar cell polarity protein 2MIM:600533Ensembl:ENSG00000162738HGNC:HGNC:15511PA379701q23.2

GO terms in VANGL2

Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0001736establishment of planar polarity
BPISSGO:0001843neural tube closure
BPIEAGO:0001942hair follicle development
BPISSGO:0001947heart looping
BPIEAGO:0003149membranous septum morphogenesis
BPIEAGO:0003150muscular septum morphogenesis
BPIEAGO:0003402planar cell polarity pathway involved in axis elongation
BPIEAGO:0007266Rho protein signal transduction
BPIEAGO:0009952anterior/posterior pattern specification
BPIEAGO:0015012heparan sulfate proteoglycan biosynthetic process
BPIEAGO:0022007convergent extension involved in neural plate elongation
BPIEAGO:0030111regulation of Wnt signaling pathway
BPIEAGO:0032835glomerulus development
BPIEAGO:0032956regulation of actin cytoskeleton organization
BPIEAGO:0035019somatic stem cell population maintenance
BPISSGO:0035787cell migration involved in kidney development
BPIEAGO:0036342post-anal tail morphogenesis
BPIEAGO:0036514dopaminergic neuron axon guidance
BPIEAGO:0036515serotonergic neuron axon guidance
BPIEAGO:0042060wound healing
BPIEAGO:0043507positive regulation of JUN kinase activity
BPISSGO:0045176apical protein localization
BPIEAGO:0045197establishment or maintenance of epithelial cell apical/basal polarity
BPIEAGO:0048103somatic stem cell division
BPIEAGO:0048105establishment of body hair planar orientation
BPIEAGO:0048546digestive tract morphogenesis
BPIEAGO:0060028convergent extension involved in axis elongation
BPIEAGO:0060122inner ear receptor cell stereocilium organization
BPIEAGO:0060488orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
BPIEAGO:0060489planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
BPIEAGO:0060490lateral sprouting involved in lung morphogenesis
BPIEAGO:0060993kidney morphogenesis
BPIEAGO:0061346planar cell polarity pathway involved in heart morphogenesis
BPIEAGO:0090103cochlea morphogenesis
BPIEAGO:0090177establishment of planar polarity involved in neural tube closure
BPIEAGO:0090179planar cell polarity pathway involved in neural tube closure
BPIEAGO:1904938planar cell polarity pathway involved in axon guidance
BPISSGO:1905515non-motile cilium assembly
CCIEAGO:0001725stress fiber
CCTASGO:0005886plasma membrane
CCISSGO:0005911cell-cell junction
CCIEAGO:0016021integral component of membrane
CCIEAGO:0016323basolateral plasma membrane
CCISSGO:0016324apical plasma membrane
CCISSGO:0016328lateral plasma membrane
CCIEAGO:0030134COPII-coated ER to Golgi transport vesicle
CCIEAGO:0060187cell pole
MFIPIGO:0005515protein binding

Gene expression in normal tissue: VANGL2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VANGL2

DatabasePathway IDPathway Des.
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
wikipathwaysWP428Wnt Signaling Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-4608870Asymmetric localization of PCP proteins

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VANGL2