Summary: The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013].

parathyroid hormone like hormoneMIM:168470Ensembl:ENSG00000087494HGNC:HGNC:9607PA3395212p11.22

GO terms in PTHLH

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCTASGO:0005615extracellular space
CCIDAGO:0005794Golgi apparatus
BPIDAGO:0001501skeletal system development
BPIBAGO:0002076osteoblast development
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway
BPIDAGO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway
BPTASGO:0007267cell-cell signaling
BPTASGO:0007565female pregnancy
BPTASGO:0008284positive regulation of cell proliferation
BPTASGO:0008285negative regulation of cell proliferation
BPTASGO:0008544epidermis development
BPIDAGO:0010468regulation of gene expression
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0030282bone mineralization
BPIBAGO:0032330regulation of chondrocyte differentiation
BPIDAGO:0032331negative regulation of chondrocyte differentiation
BPTASGO:0046058cAMP metabolic process
MFIBAGO:0005179hormone activity
MFIBAGO:0051428peptide hormone receptor binding
MFIDAGO:0051428peptide hormone receptor binding

Gene expression in normal tissue: PTHLH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTHLH

DatabasePathway IDPathway Des.
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP3872Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathwaysWP474Endochondral Ossification
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373080Class B/2 (Secretin family receptors)
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418555G alpha (s) signalling events
reactomeR-HSA-500792GPCR ligand binding

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTHLH