PLEKHG5


Summary: This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
pleckstrin homology and RhoGEF domain containing G5MIM:611101Ensembl:ENSG00000171680HGNC:HGNC:29105PA1426711641p36.31

GO terms in PLEKHG5


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005085guanyl-nucleotide exchange factor activity
MFTASGO:0005089Rho guanyl-nucleotide exchange factor activity
CCISSGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCISSGO:0005911cell-cell junction
CCISSGO:0030027lamellipodium
CCISSGO:0030139endocytic vesicle
CCIEAGO:0048471perinuclear region of cytoplasm
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0035023regulation of Rho protein signal transduction
BPISSGO:0035767endothelial cell chemotaxis
BPTASGO:0043065positive regulation of apoptotic process
BPHMPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPTASGO:0051056regulation of small GTPase mediated signal transduction

Gene expression in normal tissue: PLEKHG5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLEKHG5


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-73887Death Receptor Signalling
kegghsa05200Pathways in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLEKHG5

​​​​