SLC12A5
Summary: K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 12 member 5 | MIM:606726 | Ensembl:ENSG00000124140 | HGNC:HGNC:13818 | PA37814 | 20q13.12 |
GO terms in SLC12A5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0043198 | dendritic shaft |
| BP | IDA | GO:0006811 | ion transport |
| BP | TAS | GO:0006811 | ion transport |
| BP | IDA | GO:0006873 | cellular ion homeostasis |
| BP | IBA | GO:0006884 | cell volume homeostasis |
| BP | IDA | GO:0006971 | hypotonic response |
| BP | IBA | GO:0007268 | chemical synaptic transmission |
| BP | IEA | GO:0007612 | learning |
| BP | IBA | GO:0010107 | potassium ion import |
| BP | IDA | GO:0030644 | cellular chloride ion homeostasis |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IEA | GO:0040040 | thermosensory behavior |
| BP | IEA | GO:0042493 | response to drug |
| BP | IBA | GO:0055064 | chloride ion homeostasis |
| BP | IBA | GO:0055075 | potassium ion homeostasis |
| BP | IDA | GO:0060996 | dendritic spine development |
| BP | IEA | GO:0071805 | potassium ion transmembrane transport |
| BP | IBA | GO:1902476 | chloride transmembrane transport |
| BP | IEA | GO:1902476 | chloride transmembrane transport |
| MF | IDA | GO:0015108 | chloride transmembrane transporter activity |
| MF | IBA | GO:0015379 | potassium:chloride symporter activity |
| MF | IDA | GO:0015379 | potassium:chloride symporter activity |
| MF | TAS | GO:0015379 | potassium:chloride symporter activity |
Gene expression in normal tissue: SLC12A5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC12A5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-426117 | Cation-coupled Chloride cotransporters |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC12A5
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