Summary: K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008].

solute carrier family 12 member 5MIM:606726Ensembl:ENSG00000124140HGNC:HGNC:13818PA3781420q13.12

GO terms in SLC12A5

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCIDAGO:0016021integral component of membrane
CCIEAGO:0043025neuronal cell body
CCIEAGO:0043198dendritic shaft
BPIDAGO:0006811ion transport
BPTASGO:0006811ion transport
BPIDAGO:0006873cellular ion homeostasis
BPIBAGO:0006884cell volume homeostasis
BPIDAGO:0006971hypotonic response
BPIBAGO:0007268chemical synaptic transmission
BPIBAGO:0010107potassium ion import
BPIDAGO:0030644cellular chloride ion homeostasis
BPIEAGO:0035264multicellular organism growth
BPIEAGO:0040040thermosensory behavior
BPIEAGO:0042493response to drug
BPIBAGO:0055064chloride ion homeostasis
BPIBAGO:0055075potassium ion homeostasis
BPIDAGO:0060996dendritic spine development
BPIEAGO:0071805potassium ion transmembrane transport
BPIBAGO:1902476chloride transmembrane transport
BPIEAGO:1902476chloride transmembrane transport
MFIDAGO:0015108chloride transmembrane transporter activity
MFIBAGO:0015379potassium:chloride symporter activity
MFIDAGO:0015379potassium:chloride symporter activity
MFTASGO:0015379potassium:chloride symporter activity

Gene expression in normal tissue: SLC12A5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC12A5

DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptides
reactomeR-HSA-425407SLC-mediated transmembrane transport
reactomeR-HSA-426117Cation-coupled Chloride cotransporters
kegghsa04727GABAergic synapse - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC12A5