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SRGAP1

Summary: The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
SLIT-ROBO Rho GTPase activating protein 1	MIM:606523	Ensembl:ENSG00000196935	HGNC:HGNC:17382	PA134887956	12q14.2

GO terms in SRGAP1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0005096	GTPase activator activity
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0048365	Rac GTPase binding
CC	IBA	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
BP	IEA	GO:0007165	signal transduction
BP	IBA	GO:0030336	negative regulation of cell migration
BP	IEA	GO:0043547	positive regulation of GTPase activity
BP	TAS	GO:0051056	regulation of small GTPase mediated signal transduction

Gene expression in normal tissue: SRGAP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SRGAP1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-194840	Rho GTPase cycle
reactome	R-HSA-376176	Signaling by ROBO receptors
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-428543	Inactivation of CDC42 and RAC1
pid	rhoa_reg_pathway	Regulation of RhoA activity
kegg	hsa04360	Axon guidance - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD292	NSC87877	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRGAP1

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