SRGAP1

Summary: The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSLIT-ROBO Rho GTPase activating protein 1
OMIM IDMIM:606523
Ensembl IDEnsembl:ENSG00000196935
HGNC IDHGNC:HGNC:17382
PHARMGKB IDPA134887956
Map Location12q14.2

GO terms in SRGAP1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0005096 GTPase activator activity
MF IPI GO:0005515 protein binding
MF IBA GO:0048365 Rac GTPase binding
CC IBA GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
BP IEA GO:0007165 signal transduction
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Gene expression in normal tissue: SRGAP1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

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Pathways in SRGAP1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-194315 Signaling by Rho GTPases
reactome R-HSA-194840 Rho GTPase cycle
reactome R-HSA-376176 Signaling by ROBO receptors
reactome R-HSA-422475 Axon guidance
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD292 NSC87877 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRGAP1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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