NCOA5


Summary: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear receptor coactivator 5MIM:616825Ensembl:ENSG00000124160HGNC:HGNC:15909PA3147420q13.12

GO terms in NCOA5


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003682chromatin binding
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0042593glucose homeostasis
BPIEAGO:0046627negative regulation of insulin receptor signaling pathway
CCHDAGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCIDAGO:0015629actin cytoskeleton

Gene expression in normal tissue: NCOA5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NCOA5


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NCOA5

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