NCOA5

Summary: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenuclear receptor coactivator 5
OMIM IDMIM:616825
Ensembl IDEnsembl:ENSG00000124160
HGNC IDHGNC:HGNC:15909
PHARMGKB IDPA31474
Map Location20q13.12

GO terms in NCOA5


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003682 chromatin binding
MF HDA GO:0003723 RNA binding
MF IPI GO:0005515 protein binding
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0006355 regulation of transcription, DNA-templated
BP IEA GO:0042593 glucose homeostasis
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Gene expression in normal tissue: NCOA5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in NCOA5


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NCOA5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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