PTPN12
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600079 Ensembl IDEnsembl:ENSG00000127947 HGNC IDHGNC:HGNC:9645 PHARMGKB IDPA33987 Map Location7q11.23 | |||||
GO terms in PTPN12
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006470 | protein dephosphorylation |
| BP | IDA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | IMP | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway |
| BP | IEA | GO:0042246 | tissue regeneration |
| BP | TAS | GO:0071345 | cellular response to cytokine stimulus |
Gene expression in normal tissue: PTPN12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPN12
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPN12
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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