PTPRB
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, receptor type B | MIM:176882 | Ensembl:ENSG00000127329 | HGNC:HGNC:9665 | PA34010 | 12q15 |
GO terms in PTPRB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | IDA | GO:0043235 | receptor complex |
| CC | TAS | GO:0070821 | tertiary granule membrane |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | TAS | GO:0006470 | protein dephosphorylation |
| BP | TAS | GO:0006796 | phosphate-containing compound metabolic process |
| BP | IDA | GO:0016311 | dephosphorylation |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
Gene expression in normal tissue: PTPRB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| wikipathways | WP2858 | Ectoderm Differentiation |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRB
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