PTPRK
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602545 Ensembl IDEnsembl:ENSG00000152894 HGNC IDHGNC:HGNC:9674 PHARMGKB IDPA34019 Map Location6q22.33 | |||||
GO terms in PTPRK
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | NAS | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0045295 | gamma-catenin binding |
Gene expression in normal tissue: PTPRK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRK
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRK
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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