Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008].

protein tyrosine phosphatase, receptor type KMIM:602545Ensembl:ENSG00000152894HGNC:HGNC:9674PA340196q22.33

GO terms in PTPRK

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004725protein tyrosine phosphatase activity
MFNASGO:0005001transmembrane receptor protein tyrosine phosphatase activity
MFIPIGO:0005515protein binding
MFIPIGO:0008013beta-catenin binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0045295gamma-catenin binding
CCIEAGO:0001750photoreceptor outer segment
CCIDAGO:0005886plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCIDAGO:0005911cell-cell junction
CCIEAGO:0005912adherens junction
CCIDAGO:0009986cell surface
CCNASGO:0016021integral component of membrane
CCIDAGO:0030054cell junction
CCIDAGO:0031256leading edge membrane
CCIEAGO:0043025neuronal cell body
CCIDAGO:0043231intracellular membrane-bounded organelle
BPIDAGO:0006470protein dephosphorylation
BPIMPGO:0007155cell adhesion
BPIDAGO:0007165signal transduction
BPIDAGO:0007179transforming growth factor beta receptor signaling pathway
BPIDAGO:0008285negative regulation of cell proliferation
BPIDAGO:0010839negative regulation of keratinocyte proliferation
BPIMPGO:0016477cell migration
BPIDAGO:0030336negative regulation of cell migration
BPIEAGO:0031175neuron projection development
BPIDAGO:0034394protein localization to cell surface
BPIDAGO:0034614cellular response to reactive oxygen species
BPIDAGO:0034644cellular response to UV
BPIEAGO:0035335peptidyl-tyrosine dephosphorylation
BPIDAGO:0045786negative regulation of cell cycle
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0048041focal adhesion assembly

Gene expression in normal tissue: PTPRK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTPRK

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-182971EGFR downregulation
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTPRK