Summary: This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

nectin cell adhesion molecule 2MIM:600798Ensembl:ENSG00000130202HGNC:HGNC:9707PA3405219q13.32

GO terms in NECTIN2

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001618virus receptor activity
MFIPIGO:0005515protein binding
MFTASGO:0015026coreceptor activity
MFIPIGO:0042802identical protein binding
MFIPIGO:0050839cell adhesion molecule binding
CCTASGO:0005886plasma membrane
CCIDAGO:0005911cell-cell junction
CCISSGO:0005915zonula adherens
CCHDAGO:0005925focal adhesion
CCIDAGO:0009986cell surface
CCIDAGO:0016021integral component of membrane
CCIEAGO:0044291cell-cell contact zone
CCHDAGO:0070062extracellular exosome
BPIEAGO:0001675acrosome assembly
BPIMPGO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
BPIMPGO:0002891positive regulation of immunoglobulin mediated immune response
BPIEAGO:0007010cytoskeleton organization
BPIDAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPIEAGO:0007165signal transduction
BPISSGO:0007286spermatid development
BPIEAGO:0007289spermatid nucleus differentiation
BPIDAGO:0019064fusion of virus membrane with host plasma membrane
BPIEAGO:0030382sperm mitochondrion organization
BPIEAGO:0032990cell part morphogenesis
BPIMPGO:0033005positive regulation of mast cell activation
BPTASGO:0034332adherens junction organization
BPIMPGO:0042271susceptibility to natural killer cell mediated cytotoxicity
BPIDAGO:0044406adhesion of symbiont to host
BPIEAGO:0044782cilium organization
BPIMPGO:0045954positive regulation of natural killer cell mediated cytotoxicity
BPIDAGO:0046596regulation of viral entry into host cell
BPIDAGO:0046814coreceptor-mediated virion attachment to host cell
BPTASGO:0050776regulation of immune response
BPIDAGO:0050862positive regulation of T cell receptor signaling pathway
BPIEAGO:0051654establishment of mitochondrion localization
BPIDAGO:0060370susceptibility to T cell mediated cytotoxicity

Gene expression in normal tissue: NECTIN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NECTIN2

DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactomeR-HSA-418990Adherens junctions interactions
reactomeR-HSA-420597Nectin/Necl trans heterodimerization
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-446728Cell junction organization
wikipathwaysWP727Monoamine Transport
pidecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
pidnectin_pathwayNectin adhesion pathway
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NECTIN2