PYGM


Summary: This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glycogen phosphorylase, muscle associatedMIM:608455Ensembl:ENSG00000068976HGNC:HGNC:9726PA3406911q13.1

Gene Categories:

DRUGGABLE GENOME

GO terms in PYGM


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0005977glycogen metabolic process
BPIBAGO:0005980glycogen catabolic process
BPTASGO:0005980glycogen catabolic process
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCHDAGO:0070062extracellular exosome
MFIEAGO:0000166nucleotide binding
MFIPIGO:0005515protein binding
MFIBAGO:0008184glycogen phosphorylase activity
MFIBAGO:0030170pyridoxal phosphate binding
MFIEAGO:0102250linear malto-oligosaccharide phosphorylase activity
MFIEAGO:0102499SHG alpha-glucan phosphorylase activity

Gene expression in normal tissue: PYGM

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PYGM


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-70221Glycogen breakdown (glycogenolysis)
reactomeR-HSA-70221Glycogen breakdown (glycogenolysis)
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-8982491Glycogen metabolism
reactomeR-HSA-8982491Glycogen metabolism
wikipathwaysWP500Glycogen Metabolism
humancycPWY-5941glycogenolysis
kegghsa00500Starch and sucrose metabolism - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD12Bicalutamide1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PYGM

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