JAM2

Summary: This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namejunctional adhesion molecule 2
OMIM IDMIM:606870
Ensembl IDEnsembl:ENSG00000154721
HGNC IDHGNC:HGNC:14686
PHARMGKB IDPA29992
Map Location21q21.3

Gene Categories:

DRUGGABLE GENOME

GO terms in JAM2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IEA GO:0046982 protein heterodimerization activity
CC TAS GO:0005886 plasma membrane
CC NAS GO:0005887 integral component of plasma membrane
CC IEA GO:0005923 bicellular tight junction
BP IEA GO:0007162 negative regulation of cell adhesion
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Gene expression in normal tissue: JAM2

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in JAM2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-202733 Cell surface interactions at the vascular wall
reactome R-HSA-216083 Integrin cell surface interactions
kegg hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegg hsa04530 Tight junction - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JAM2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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