PRUNE1

Summary: This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameprune exopolyphosphatase 1
OMIM IDMIM:617413
Ensembl IDEnsembl:ENSG00000143363
HGNC IDHGNC:HGNC:13420
PHARMGKB IDPA134939749
Map Location1q21.3

GO terms in PRUNE1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0006798 polyphosphate catabolic process
BP IEA GO:0016311 dephosphorylation
BP IMP GO:0031113 regulation of microtubule polymerization
BP IMP GO:0050767 regulation of neurogenesis
CC IEA GO:0005634 nucleus
CC IBA GO:0005737 cytoplasm
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Gene expression in normal tissue: PRUNE1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRUNE1


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Database
Pathway ID
Pathway Des.
kegg hsa00230 Purine metabolism - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRUNE1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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