PRUNE1
Summary: This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| prune exopolyphosphatase 1 | MIM:617413 | Ensembl:ENSG00000143363 | HGNC:HGNC:13420 | PA134939749 | 1q21.3 |
GO terms in PRUNE1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006798 | polyphosphate catabolic process |
| BP | IEA | GO:0016311 | dephosphorylation |
| BP | IMP | GO:0031113 | regulation of microtubule polymerization |
| BP | IMP | GO:0050767 | regulation of neurogenesis |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0005925 | focal adhesion |
| MF | IBA | GO:0004309 | exopolyphosphatase activity |
| MF | IEA | GO:0004427 | inorganic diphosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0015631 | tubulin binding |
| MF | IDA | GO:0016791 | phosphatase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: PRUNE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRUNE1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRUNE1
CLASSFICATION
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