RRAGD
Summary: RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Ras related GTP binding D | MIM:608268 | Ensembl:ENSG00000025039 | HGNC:HGNC:19903 | PA134957148 | 6q15 |
Gene Categories:
TUMOR SUPPRESSORGO terms in RRAGD
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | IBA | GO:0009267 | cellular response to starvation |
| BP | IBA | GO:0010506 | regulation of autophagy |
| BP | TAS | GO:0016241 | regulation of macroautophagy |
| BP | IBA | GO:0032008 | positive regulation of TOR signaling |
| BP | NAS | GO:0032008 | positive regulation of TOR signaling |
| BP | ISS | GO:0034613 | cellular protein localization |
| BP | IBA | GO:0071230 | cellular response to amino acid stimulus |
| BP | ISS | GO:0071230 | cellular response to amino acid stimulus |
| BP | IMP | GO:0071233 | cellular response to leucine |
| BP | IMP | GO:1904263 | positive regulation of TORC1 signaling |
| BP | IMP | GO:1990253 | cellular response to leucine starvation |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005764 | lysosome |
| CC | IDA | GO:0005764 | lysosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0034448 | EGO complex |
| CC | IBA | GO:1990131 | Gtr1-Gtr2 GTPase complex |
| MF | IBA | GO:0003924 | GTPase activity |
| MF | IMP | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0005525 | GTP binding |
| MF | IMP | GO:0019003 | GDP binding |
| MF | IMP | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0051020 | GTPase binding |
Gene expression in normal tissue: RRAGD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RRAGD
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1632852 | Macroautophagy |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-166208 | mTORC1-mediated signalling |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| pid | mtor_4pathway | mTOR signaling pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RRAGD
CLASSFICATION
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