QARS
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603727 Ensembl IDEnsembl:ENSG00000172053 HGNC IDHGNC:HGNC:9751 PHARMGKB IDPA34093 Map Location3p21.31 | |||||
GO terms in QARS
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004819 | glutamine-tRNA ligase activity |
| MF | IDA | GO:0004819 | glutamine-tRNA ligase activity |
| MF | TAS | GO:0004819 | glutamine-tRNA ligase activity |
| MF | IMP | GO:0004860 | protein kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: QARS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in QARS
Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00072 | Glutamate Metabolism |
| smpdb | SMP00136 | 2-Hydroxyglutric Aciduria (D And L Form) |
| smpdb | SMP00243 | 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency |
| smpdb | SMP00339 | Hyperinsulinism-Hyperammonemia Syndrome |
| smpdb | SMP00385 | Homocarnosinosis |
| smpdb | SMP00567 | Succinic semialdehyde dehydrogenase deficiency |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in QARS
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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