RAD51C


Summary: This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602774
PHARMGKB IDPA34177
Map Location17q22

GO terms in RAD51C


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000400 four-way junction DNA binding
MF TAS GO:0003677 DNA binding
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IMP GO:0008821 crossover junction endodeoxyribonuclease activity
CC IDA GO:0005634 nucleus
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Gene expression in normal tissue: RAD51C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

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Pathways in RAD51C


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-1474165 Reproduction
reactome R-HSA-1500620 Meiosis
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-5685942 HDR through Homologous Recombination (HRR)
reactome R-HSA-5693532 DNA Double-Strand Break Repair
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD971 PARP inhibitor 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAD51C

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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