Summary: This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

RAD51 paralog CMIM:602774Ensembl:ENSG00000108384HGNC:HGNC:9820PA3417717q22

GO terms in RAD51C

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000400four-way junction DNA binding
MFTASGO:0003677DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIMPGO:0008821crossover junction endodeoxyribonuclease activity
CCIBAGO:0005657replication fork
CCIDAGO:0005657replication fork
CCIDAGO:0030054cell junction
CCIBAGO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex
CCIDAGO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex
CCIDAGO:0033065Rad51C-XRCC3 complex
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIDAGO:0048471perinuclear region of cytoplasm
CCIDAGO:0048476Holliday junction resolvase complex
BPIBAGO:0000707meiotic DNA recombinase assembly
BPIEAGO:0000722telomere maintenance via recombination
BPIMPGO:0000724double-strand break repair via homologous recombination
BPIDAGO:0006281DNA repair
BPIDAGO:0006310DNA recombination
BPISSGO:0007062sister chromatid cohesion
BPIEAGO:0007066female meiosis sister chromatid cohesion
BPIBAGO:0007131reciprocal meiotic recombination
BPIEAGO:0007141male meiosis I
BPTASGO:0007596blood coagulation
BPIMPGO:0010971positive regulation of G2/M transition of mitotic cell cycle

Gene expression in normal tissue: RAD51C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAD51C

DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693537Resolution of D-Loop Structures
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693568Resolution of D-loop Structures through Holliday Junction Intermediates
reactomeR-HSA-5693579Homologous DNA Pairing and Strand Exchange
reactomeR-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchange
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-912446Meiotic recombination
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
kegghsa03440Homologous recombination - Homo sapiens (human)
kegghsa03460Fanconi anemia pathway - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD971PARP inhibitor2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAD51C