RAP2B
Summary: This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAP2B, member of RAS oncogene family | MIM:179541 | Ensembl:ENSG00000181467 | HGNC:HGNC:9862 | PA34223 | 3q25.2 |
GO terms in RAP2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005525 | GTP binding |
| MF | IDA | GO:0019003 | GDP binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005923 | bicellular tight junction |
| CC | IMP | GO:0016020 | membrane |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | IDA | GO:0044291 | cell-cell contact zone |
| CC | IMP | GO:0045121 | membrane raft |
| CC | ISS | GO:0055038 | recycling endosome membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0070821 | tertiary granule membrane |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IMP | GO:0030033 | microvillus assembly |
| BP | IDA | GO:0030168 | platelet activation |
| BP | IEA | GO:0030336 | negative regulation of cell migration |
| BP | IEA | GO:0031954 | positive regulation of protein autophosphorylation |
| BP | ISS | GO:0032486 | Rap protein signal transduction |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | ISS | GO:0061097 | regulation of protein tyrosine kinase activity |
| BP | IDA | GO:0070527 | platelet aggregation |
| BP | IMP | GO:0090557 | establishment of endothelial intestinal barrier |
Gene expression in normal tissue: RAP2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAP2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | plcepathway | phospholipase c-epsilon pathway |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAP2B
CLASSFICATION
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