RBBP4
Summary: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602923 Ensembl IDEnsembl:ENSG00000162521 HGNC IDHGNC:HGNC:9887 PHARMGKB IDPA34251 Map Location1p35.1 | |||||
GO terms in RBBP4
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | HDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | TAS | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008094 | DNA-dependent ATPase activity |
| MF | HDA | GO:0031492 | nucleosomal DNA binding |
Gene expression in normal tissue: RBBP4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RBBP4
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2916 | Interactome of polycomb repressive complex 2 (PRC2) |
| wikipathways | WP4204 | Tumor suppressor activity of SMARCB1 |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| pid | e2f_pathway | E2F transcription factor network |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RBBP4
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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