RBBP6
Summary: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RB binding protein 6, ubiquitin ligase | MIM:600938 | Ensembl:ENSG00000122257 | HGNC:HGNC:9889 | PA34253 | 16p12.1 |
GO terms in RBBP6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | EXP | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | TAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IMP | GO:0061630 | ubiquitin protein ligase activity |
| CC | IEA | GO:0005694 | chromosome |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0032991 | protein-containing complex |
| BP | TAS | GO:0000209 | protein polyubiquitination |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0006260 | DNA replication |
| BP | IMP | GO:0006275 | regulation of DNA replication |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | IDA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IEA | GO:0048568 | embryonic organ development |
| BP | IEA | GO:0061053 | somite development |
Gene expression in normal tissue: RBBP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RBBP6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RBBP6
CLASSFICATION
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