SENP2
Summary: SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SUMO specific peptidase 2 | MIM:608261 | Ensembl:ENSG00000163904 | HGNC:HGNC:23116 | PA134955185 | 3q27.2 |
GO terms in SENP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0007507 | heart development |
| BP | IEA | GO:0009950 | dorsal/ventral axis specification |
| BP | IEA | GO:0015031 | protein transport |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0016925 | protein sumoylation |
| BP | IBA | GO:0016926 | protein desumoylation |
| BP | IDA | GO:0016926 | protein desumoylation |
| BP | IMP | GO:0016926 | protein desumoylation |
| BP | NAS | GO:0030111 | regulation of Wnt signaling pathway |
| BP | IDA | GO:0031397 | negative regulation of protein ubiquitination |
| BP | IMP | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IMP | GO:0031648 | protein destabilization |
| BP | IEA | GO:0032091 | negative regulation of protein binding |
| BP | IEA | GO:0032875 | regulation of DNA endoreduplication |
| BP | IEA | GO:0035562 | negative regulation of chromatin binding |
| BP | IEA | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| BP | ISS | GO:0045444 | fat cell differentiation |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051028 | mRNA transport |
| BP | IEA | GO:0060707 | trophoblast giant cell differentiation |
| BP | IEA | GO:0060711 | labyrinthine layer development |
| BP | IEA | GO:0060712 | spongiotrophoblast layer development |
| BP | IEA | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005643 | nuclear pore |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | ISS | GO:0016605 | PML body |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| CC | IEA | GO:0031965 | nuclear membrane |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | EXP | GO:0070139 | SUMO-specific endopeptidase activity |
| MF | IDA | GO:0070139 | SUMO-specific endopeptidase activity |
| MF | IEA | GO:0070140 | SUMO-specific isopeptidase activity |
Gene expression in normal tissue: SENP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SENP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3065679 | SUMO is proteolytically processed |
| reactome | R-HSA-3215018 | Processing and activation of SUMO |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| wikipathways | WP428 | Wnt Signaling Pathway |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SENP2
CLASSFICATION
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