RNASE2


Summary: The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribonuclease A family member 2MIM:131410Ensembl:ENSG00000169385HGNC:HGNC:10045PA3441314q11.2

Gene Categories:

DRUGGABLE GENOME

GO terms in RNASE2


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0001530lipopolysaccharide binding
MFIEAGO:0003676nucleic acid binding
MFIBAGO:0004519endonuclease activity
MFIEAGO:0004522ribonuclease A activity
MFIBAGO:0004540ribonuclease activity
MFIDAGO:0004540ribonuclease activity
BPTASGO:0006401RNA catabolic process
BPIDAGO:0006935chemotaxis
BPIMPGO:0043152induction of bacterial agglutination
BPTASGO:0043312neutrophil degranulation
BPIMPGO:0050829defense response to Gram-negative bacterium
BPIMPGO:0050830defense response to Gram-positive bacterium
BPIDAGO:0051607defense response to virus
BPIDAGO:0090501RNA phosphodiester bond hydrolysis
BPIEAGO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic
CCTASGO:0005576extracellular region
CCTASGO:0035578azurophil granule lumen
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: RNASE2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RNASE2


DatabasePathway IDPathway Des.
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RNASE2

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