BCL7A
Summary: This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:601406 Ensembl IDEnsembl:ENSG00000110987 HGNC IDHGNC:HGNC:1004 PHARMGKB IDPA25314 Map Location12q24.31 |
GO terms in BCL7A
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | ND | GO:0003674 | molecular_function |
MF | IPI | GO:0005515 | protein binding |
BP | NAS | GO:0045892 | negative regulation of transcription, DNA-templated |
CC | ND | GO:0005575 | cellular_component |
Showing 1 to 4 of 4 rows
Gene expression in normal tissue: BCL7A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL7A
Loading, please wait...
Database | Pathway ID | Pathway Des. |
---|---|---|
netpath | Pathway_TNFalpha | TNFalpha |
Showing 1 to 1 of 1 rows
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in BCL7A
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |