BCL7A


Summary: This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:601406
PHARMGKB IDPA25314
Map Location12q24.31

GO terms in BCL7A


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ND GO:0003674 molecular_function
MF IPI GO:0005515 protein binding
BP NAS GO:0045892 negative regulation of transcription, DNA-templated
CC ND GO:0005575 cellular_component
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Gene expression in normal tissue: BCL7A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL7A


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Database
Pathway ID
Pathway Des.
netpath Pathway_TNFalpha TNFalpha
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 2
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL7A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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