BCL7A


Summary: This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BCL tumor suppressor 7AMIM:601406Ensembl:ENSG00000110987HGNC:HGNC:1004PA2531412q24.31

GO terms in BCL7A


Term TypeEvidence TypeGO Term IDGO Des.
MFNDGO:0003674molecular_function
MFIPIGO:0005515protein binding
BPNASGO:0045892negative regulation of transcription, DNA-templated
CCNDGO:0005575cellular_component

Gene expression in normal tissue: BCL7A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL7A


DatabasePathway IDPathway Des.
netpathPathway_TNFalphaTNFalpha

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL7A

​​​​