RPA2
Summary: This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| replication protein A2 | MIM:179836 | Ensembl:ENSG00000117748 | HGNC:HGNC:10290 | PA34652 | 1p35.3 |
GO terms in RPA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IC | GO:0000723 | telomere maintenance |
| BP | IMP | GO:0000723 | telomere maintenance |
| BP | IMP | GO:0000724 | double-strand break repair via homologous recombination |
| BP | IDA | GO:0006260 | DNA replication |
| BP | IMP | GO:0006260 | DNA replication |
| BP | TAS | GO:0006260 | DNA replication |
| BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | IDA | GO:0006284 | base-excision repair |
| BP | IMP | GO:0006289 | nucleotide-excision repair |
| BP | TAS | GO:0006293 | nucleotide-excision repair, preincision complex stabilization |
| BP | TAS | GO:0006294 | nucleotide-excision repair, preincision complex assembly |
| BP | TAS | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| BP | TAS | GO:0006297 | nucleotide-excision repair, DNA gap filling |
| BP | IMP | GO:0006298 | mismatch repair |
| BP | IMP | GO:0010569 | regulation of double-strand break repair via homologous recombination |
| BP | TAS | GO:0019985 | translesion synthesis |
| BP | IMP | GO:0031571 | mitotic G1 DNA damage checkpoint |
| BP | TAS | GO:0032201 | telomere maintenance via semi-conservative replication |
| BP | TAS | GO:0033683 | nucleotide-excision repair, DNA incision |
| BP | IDA | GO:0034502 | protein localization to chromosome |
| BP | TAS | GO:0036297 | interstrand cross-link repair |
| BP | TAS | GO:0042276 | error-prone translesion synthesis |
| BP | TAS | GO:0042769 | DNA damage response, detection of DNA damage |
| BP | TAS | GO:0070987 | error-free translesion synthesis |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| BP | IMP | GO:2000001 | regulation of DNA damage checkpoint |
| CC | IDA | GO:0000781 | chromosome, telomeric region |
| CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0000785 | chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005662 | DNA replication factor A complex |
| CC | IPI | GO:0005662 | DNA replication factor A complex |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0016605 | PML body |
| CC | IDA | GO:0016605 | PML body |
| CC | IDA | GO:0035861 | site of double-strand break |
| MF | IBA | GO:0003684 | damaged DNA binding |
| MF | IDA | GO:0003684 | damaged DNA binding |
| MF | IBA | GO:0003690 | double-stranded DNA binding |
| MF | IBA | GO:0003697 | single-stranded DNA binding |
| MF | IC | GO:0003697 | single-stranded DNA binding |
| MF | IDA | GO:0003697 | single-stranded DNA binding |
| MF | ISS | GO:0003697 | single-stranded DNA binding |
| MF | IBA | GO:0005515 | protein binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IEA | GO:0047485 | protein N-terminus binding |
| MF | IBA | GO:0098505 | G-rich strand telomeric DNA binding |
| MF | IDA | GO:0098505 | G-rich strand telomeric DNA binding |
Gene expression in normal tissue: RPA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-110312 | Translesion synthesis by REV1 |
| reactome | R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| reactome | R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex |
| reactome | R-HSA-110320 | Translesion Synthesis by POLH |
| reactome | R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-157579 | Telomere Maintenance |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174414 | Processive synthesis on the C-strand of the telomere |
| reactome | R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis |
| reactome | R-HSA-174437 | Removal of the Flap Intermediate from the C-strand |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-180786 | Extension of Telomeres |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371511 | HSF1 activation |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-5358508 | Mismatch Repair |
| reactome | R-HSA-5358508 | Mismatch Repair |
| reactome | R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| reactome | R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| reactome | R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair |
| reactome | R-HSA-5655862 | Translesion synthesis by POLK |
| reactome | R-HSA-5656121 | Translesion synthesis by POLI |
| reactome | R-HSA-5656169 | Termination of translesion DNA synthesis |
| reactome | R-HSA-5685938 | HDR through Single Strand Annealing (SSA) |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange |
| reactome | R-HSA-5696395 | Formation of Incision Complex in GG-NER |
| reactome | R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
| reactome | R-HSA-5696400 | Dual Incision in GG-NER |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-6782135 | Dual incision in TC-NER |
| reactome | R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| reactome | R-HSA-6783310 | Fanconi Anemia Pathway |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-68874 | M/G1 Transition |
| reactome | R-HSA-68962 | Activation of the pre-replicative complex |
| reactome | R-HSA-69002 | DNA Replication Pre-Initiation |
| reactome | R-HSA-69166 | Removal of the Flap Intermediate |
| reactome | R-HSA-69183 | Processive synthesis on the lagging strand |
| reactome | R-HSA-69186 | Lagging Strand Synthesis |
| reactome | R-HSA-69190 | DNA strand elongation |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73884 | Base Excision Repair |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| reactome | R-HSA-73893 | DNA Damage Bypass |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73933 | Resolution of Abasic Sites (AP sites) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-912446 | Meiotic recombination |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP466 | DNA Replication |
| wikipathways | WP707 | DNA Damage Response |
| kegg | hsa03030 | DNA replication - Homo sapiens (human) |
| kegg | hsa03420 | Nucleotide excision repair - Homo sapiens (human) |
| kegg | hsa03430 | Mismatch repair - Homo sapiens (human) |
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| kegg | hsa03460 | Fanconi anemia pathway - Homo sapiens (human) |
| pid | atr_pathway | ATR signaling pathway |
| pid | fanconi_pathway | Fanconi anemia pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPA2
CLASSFICATION
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