RPL6
Summary: This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603703 Ensembl IDEnsembl:ENSG00000089009 HGNC IDHGNC:HGNC:10362 PHARMGKB IDPA34758 Map Location12q24.13 | |||||
GO terms in RPL6
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003735 | structural constituent of ribosome |
| MF | NAS | GO:0003735 | structural constituent of ribosome |
| MF | HDA | GO:0045296 | cadherin binding |
| BP | IBA | GO:0000027 | ribosomal large subunit assembly |
Gene expression in normal tissue: RPL6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPL6
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
| reactome | R-HSA-156902 | Peptide chain elongation |
| reactome | R-HSA-1643685 | Disease |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPL6
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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