RPL7A


Summary: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribosomal protein L7aMIM:185640Ensembl:ENSG00000148303HGNC:HGNC:10364PA347609q34.2

GO terms in RPL7A


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIBAGO:0003723RNA binding
MFNASGO:0003735structural constituent of ribosome
MFIPIGO:0005515protein binding
MFHDAGO:0045296cadherin binding
BPTASGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPIBAGO:0000470maturation of LSU-rRNA
BPIBAGO:0006412translation
BPNASGO:0006412translation
BPTASGO:0006413translational initiation
BPTASGO:0006614SRP-dependent cotranslational protein targeting to membrane
CCHDAGO:0005634nucleus
CCHDAGO:0005730nucleolus
CCHDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCHDAGO:0005925focal adhesion
CCIDAGO:0016020membrane
CCHDAGO:0022625cytosolic large ribosomal subunit
CCIBAGO:0022625cytosolic large ribosomal subunit
CCIDAGO:0042788polysomal ribosome

Gene expression in normal tissue: RPL7A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPL7A


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expression
reactomeR-HSA-156842Eukaryotic Translation Elongation
reactomeR-HSA-156902Peptide chain elongation
reactomeR-HSA-1643685Disease
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168255Influenza Life Cycle
reactomeR-HSA-168273Influenza Viral RNA Transcription and Replication
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-192823Viral mRNA Translation
reactomeR-HSA-2408522Selenoamino acid metabolism
reactomeR-HSA-2408557Selenocysteine synthesis
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-71291Metabolism of amino acids and derivatives
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-72613Eukaryotic Translation Initiation
reactomeR-HSA-72689Formation of a pool of free 40S subunits
reactomeR-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunit
reactomeR-HSA-72737Cap-dependent Translation Initiation
reactomeR-HSA-72764Eukaryotic Translation Termination
reactomeR-HSA-72766Translation
reactomeR-HSA-72766Translation
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-927802Nonsense-Mediated Decay (NMD)
reactomeR-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
reactomeR-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
kegghsa03010Ribosome - Homo sapiens (human)
wikipathwaysWP477Cytoplasmic Ribosomal Proteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPL7A

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