RPL8
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604177 Ensembl IDEnsembl:ENSG00000161016 HGNC IDHGNC:HGNC:10368 PHARMGKB IDPA34768 Map Location8q24.3 | |||||
GO terms in RPL8
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | HDA | GO:0022625 | cytosolic large ribosomal subunit |
| CC | IBA | GO:0022625 | cytosolic large ribosomal subunit |
| CC | IDA | GO:0022625 | cytosolic large ribosomal subunit |
Gene expression in normal tissue: RPL8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPL8
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa03010 | Ribosome - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPL8
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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