RPL36A
Summary: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Naturally occurring read-through transcription occurs between this locus and the heterogeneous nuclear ribonucleoprotein H2 (H') gene. [provided by RefSeq, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribosomal protein L36a | MIM:300902 | Ensembl:ENSG00000241343 | HGNC:HGNC:10359 | PA164742367 | Xq22.1 |
GO terms in RPL36A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| BP | IC | GO:0002181 | cytoplasmic translation |
| BP | IDA | GO:0002181 | cytoplasmic translation |
| BP | NAS | GO:0006412 | translation |
| BP | TAS | GO:0006413 | translational initiation |
| BP | TAS | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | NAS | GO:0005840 | ribosome |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0022625 | cytosolic large ribosomal subunit |
| CC | IBA | GO:0022625 | cytosolic large ribosomal subunit |
| CC | IDA | GO:0022625 | cytosolic large ribosomal subunit |
| CC | IDA | GO:0042788 | polysomal ribosome |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IC | GO:0003735 | structural constituent of ribosome |
| MF | NAS | GO:0003735 | structural constituent of ribosome |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: RPL36A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPL36A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
| reactome | R-HSA-156902 | Peptide chain elongation |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-192823 | Viral mRNA Translation |
| reactome | R-HSA-2408522 | Selenoamino acid metabolism |
| reactome | R-HSA-2408557 | Selenocysteine synthesis |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72764 | Eukaryotic Translation Termination |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
| reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
| reactome | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
| kegg | hsa03010 | Ribosome - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPL36A
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