RPS8


Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:600357
PHARMGKB IDPA34856
Map Location1p34.1

GO terms in RPS8


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF HDA GO:0003723 RNA binding
MF IBA GO:0003735 structural constituent of ribosome
CC HDA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005783 endoplasmic reticulum
CC IDA GO:0005829 cytosol
Showing 1 to 6 of 21 rows rows per page

Gene expression in normal tissue: RPS8

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Metabolic pathways1

Pathways in RPS8


Loading, please wait...
Database
Pathway ID
Pathway Des.
kegg hsa03010 Ribosome - Homo sapiens (human)
wikipathways WP477 Cytoplasmic Ribosomal Proteins
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1430728 Metabolism
reactome R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
reactome R-HSA-156842 Eukaryotic Translation Elongation
Showing 1 to 6 of 41 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 2
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS8

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​