RPS12
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603660 Ensembl IDEnsembl:ENSG00000112306 HGNC IDHGNC:HGNC:10385 PHARMGKB IDPA34784 Map Location6q23.2 | |||||
GO terms in RPS12
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003735 | structural constituent of ribosome |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: RPS12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS12
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
| kegg | hsa03010 | Ribosome - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPS12
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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