RPS15


Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribosomal protein S15MIM:180535Ensembl:ENSG00000115268HGNC:HGNC:10388PA3478719p13.3

GO terms in RPS15


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0003677DNA binding
MFHDAGO:0003723RNA binding
MFIBAGO:0003735structural constituent of ribosome
MFIPIGO:0005515protein binding
BPIBAGO:0000028ribosomal small subunit assembly
BPIMPGO:0000056ribosomal small subunit export from nucleus
BPTASGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPHDAGO:0001649osteoblast differentiation
BPIMPGO:0006364rRNA processing
BPICGO:0006412translation
BPTASGO:0006413translational initiation
BPTASGO:0006614SRP-dependent cotranslational protein targeting to membrane
BPIMPGO:0042274ribosomal small subunit biogenesis
CCNASGO:0005634nucleus
CCNASGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCHDAGO:0005925focal adhesion
CCHDAGO:0016020membrane
CCHDAGO:0022627cytosolic small ribosomal subunit
CCIBAGO:0022627cytosolic small ribosomal subunit
CCIDAGO:0022627cytosolic small ribosomal subunit

Gene expression in normal tissue: RPS15

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPS15


DatabasePathway IDPathway Des.
wikipathwaysWP477Cytoplasmic Ribosomal Proteins
kegghsa03010Ribosome - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expression
reactomeR-HSA-156842Eukaryotic Translation Elongation
reactomeR-HSA-156902Peptide chain elongation
reactomeR-HSA-1643685Disease
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168255Influenza Life Cycle
reactomeR-HSA-168273Influenza Viral RNA Transcription and Replication
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-192823Viral mRNA Translation
reactomeR-HSA-2408522Selenoamino acid metabolism
reactomeR-HSA-2408557Selenocysteine synthesis
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-71291Metabolism of amino acids and derivatives
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-72613Eukaryotic Translation Initiation
reactomeR-HSA-72649Translation initiation complex formation
reactomeR-HSA-72662Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
reactomeR-HSA-72689Formation of a pool of free 40S subunits
reactomeR-HSA-72695Formation of the ternary complex, and subsequently, the 43S complex
reactomeR-HSA-72702Ribosomal scanning and start codon recognition
reactomeR-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunit
reactomeR-HSA-72737Cap-dependent Translation Initiation
reactomeR-HSA-72764Eukaryotic Translation Termination
reactomeR-HSA-72766Translation
reactomeR-HSA-72766Translation
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-927802Nonsense-Mediated Decay (NMD)
reactomeR-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
reactomeR-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS15

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