RRM1
Summary: This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:180410 Ensembl IDEnsembl:ENSG00000167325 HGNC IDHGNC:HGNC:10451 PHARMGKB IDPA298 Map Location11p15.4 | |||||
GO terms in RRM1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0006206 | pyrimidine nucleobase metabolic process |
| BP | IEA | GO:0006260 | DNA replication |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IBA | GO:0009263 | deoxyribonucleotide biosynthetic process |
| BP | ISS | GO:0009263 | deoxyribonucleotide biosynthetic process |
Gene expression in normal tissue: RRM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RRM1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-499943 | Interconversion of nucleotide di- and triphosphates |
| pid | e2f_pathway | E2F transcription factor network |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RRM1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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