RRM1
Summary: This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribonucleotide reductase catalytic subunit M1 | MIM:180410 | Ensembl:ENSG00000167325 | HGNC:HGNC:10451 | PA298 | 11p15.4 |
GO terms in RRM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0006206 | pyrimidine nucleobase metabolic process |
| BP | IEA | GO:0006260 | DNA replication |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IBA | GO:0009263 | deoxyribonucleotide biosynthetic process |
| BP | ISS | GO:0009263 | deoxyribonucleotide biosynthetic process |
| BP | IEA | GO:0010212 | response to ionizing radiation |
| BP | IEA | GO:0021846 | cell proliferation in forebrain |
| BP | IEA | GO:0051290 | protein heterotetramerization |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0060041 | retina development in camera-type eye |
| CC | IEA | GO:0005635 | nuclear envelope |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005971 | ribonucleoside-diphosphate reductase complex |
| CC | IEA | GO:0005971 | ribonucleoside-diphosphate reductase complex |
| CC | IEA | GO:0042995 | cell projection |
| CC | IEA | GO:0043025 | neuronal cell body |
| MF | IBA | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| MF | ISS | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0097718 | disordered domain specific binding |
Gene expression in normal tissue: RRM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RRM1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-499943 | Interconversion of nucleotide di- and triphosphates |
| pid | e2f_pathway | E2F transcription factor network |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| pharmgkb | PA150653776 | Fluoropyrimidine Pathway, Pharmacokinetics |
| pharmgkb | PA2036 | Gemcitabine Pathway, Pharmacodynamics |
| humancyc | PWY-7184 | pyrimidine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY-7210 | pyrimidine deoxyribonucleotides biosynthesis from CTP |
| humancyc | PWY-7211 | superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY-7226 | guanosine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY-7227 | adenosine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY-7228 | guanosine nucleotides de novo biosynthesis |
| humancyc | PWY-841 | purine nucleotides de novo biosynthesis |
| humancyc | PWY66-409 | superpathway of purine nucleotide salvage |
| wikipathways | WP1601 | Fluoropyrimidine Activity |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP4022 | Pyrimidine metabolism |
| wikipathways | WP404 | Nucleotide Metabolism |
| smpdb | SMP00050 | Purine Metabolism |
| smpdb | SMP00144 | Adenosine Deaminase Deficiency |
| smpdb | SMP00167 | Adenylosuccinate Lyase Deficiency |
| smpdb | SMP00168 | AICA-Ribosiduria |
| smpdb | SMP00203 | Molybdenum Cofactor Deficiency |
| smpdb | SMP00210 | Purine Nucleoside Phosphorylase Deficiency |
| smpdb | SMP00220 | Xanthine Dehydrogenase Deficiency (Xanthinuria) |
| smpdb | SMP00364 | Lesch-Nyhan Syndrome (LNS) |
| smpdb | SMP00365 | Gout or Kelley-Seegmiller Syndrome |
| smpdb | SMP00427 | Azathioprine Action Pathway |
| smpdb | SMP00428 | Mercaptopurine Action Pathway |
| smpdb | SMP00430 | Thioguanine Action Pathway |
| smpdb | SMP00446 | Gemcitabine Action Pathway |
| smpdb | SMP00512 | Xanthinuria type I |
| smpdb | SMP00513 | Xanthinuria type II |
| smpdb | SMP00535 | Adenine phosphoribosyltransferase deficiency (APRT) |
| smpdb | SMP00536 | Mitochondrial DNA depletion syndrome |
| smpdb | SMP00537 | Myoadenylate deaminase deficiency |
| smpdb | SMP00603 | Gemcitabine Metabolism Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RRM1
CLASSFICATION
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