RRM2
Summary: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribonucleotide reductase regulatory subunit M2 | MIM:180390 | Ensembl:ENSG00000171848 | HGNC:HGNC:10452 | PA299 | 2p25.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in RRM2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0006260 | DNA replication |
| BP | IBA | GO:0009263 | deoxyribonucleotide biosynthetic process |
| BP | ISS | GO:0009263 | deoxyribonucleotide biosynthetic process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | TAS | GO:0070317 | negative regulation of G0 to G1 transition |
| MF | IBA | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| MF | ISS | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| MF | NAS | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: RRM2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RRM2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-499943 | Interconversion of nucleotide di- and triphosphates |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953750 | Transcriptional Regulation by E2F6 |
| pid | e2f_pathway | E2F transcription factor network |
| pharmgkb | PA150653776 | Fluoropyrimidine Pathway, Pharmacokinetics |
| pharmgkb | PA2036 | Gemcitabine Pathway, Pharmacodynamics |
| humancyc | PWY-7184 | pyrimidine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY-7210 | pyrimidine deoxyribonucleotides biosynthesis from CTP |
| humancyc | PWY-7211 | superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY-7226 | guanosine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY-7227 | adenosine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY-7228 | guanosine nucleotides de novo biosynthesis |
| humancyc | PWY-841 | purine nucleotides de novo biosynthesis |
| humancyc | PWY66-409 | superpathway of purine nucleotide salvage |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| smpdb | SMP00046 | Pyrimidine Metabolism |
| smpdb | SMP00050 | Purine Metabolism |
| smpdb | SMP00144 | Adenosine Deaminase Deficiency |
| smpdb | SMP00167 | Adenylosuccinate Lyase Deficiency |
| smpdb | SMP00168 | AICA-Ribosiduria |
| smpdb | SMP00172 | Beta Ureidopropionase Deficiency |
| smpdb | SMP00178 | Dihydropyrimidinase Deficiency |
| smpdb | SMP00202 | MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) |
| smpdb | SMP00203 | Molybdenum Cofactor Deficiency |
| smpdb | SMP00210 | Purine Nucleoside Phosphorylase Deficiency |
| smpdb | SMP00219 | UMP Synthase Deiciency (Orotic Aciduria) |
| smpdb | SMP00220 | Xanthine Dehydrogenase Deficiency (Xanthinuria) |
| smpdb | SMP00364 | Lesch-Nyhan Syndrome (LNS) |
| smpdb | SMP00365 | Gout or Kelley-Seegmiller Syndrome |
| smpdb | SMP00427 | Azathioprine Action Pathway |
| smpdb | SMP00428 | Mercaptopurine Action Pathway |
| smpdb | SMP00430 | Thioguanine Action Pathway |
| smpdb | SMP00446 | Gemcitabine Action Pathway |
| smpdb | SMP00512 | Xanthinuria type I |
| smpdb | SMP00513 | Xanthinuria type II |
| smpdb | SMP00535 | Adenine phosphoribosyltransferase deficiency (APRT) |
| smpdb | SMP00536 | Mitochondrial DNA depletion syndrome |
| smpdb | SMP00537 | Myoadenylate deaminase deficiency |
| smpdb | SMP00603 | Gemcitabine Metabolism Pathway |
| wikipathways | WP1601 | Fluoropyrimidine Activity |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP4022 | Pyrimidine metabolism |
| wikipathways | WP404 | Nucleotide Metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RRM2
CLASSFICATION
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