S100P
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| S100 calcium binding protein P | MIM:600614 | Ensembl:ENSG00000163993 | HGNC:HGNC:10504 | PA34913 | 4p16.1 |
GO terms in S100P
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0000287 | magnesium ion binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0046914 | transition metal ion binding |
| MF | IPI | GO:0048306 | calcium-dependent protein binding |
| MF | IEA | GO:0050786 | RAGE receptor binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IEA | GO:0031528 | microvillus membrane |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEP | GO:0010033 | response to organic substance |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IMP | GO:0043542 | endothelial cell migration |
Gene expression in normal tissue: S100P
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in S100P
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2361 | Gastric Cancer Network 1 |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in S100P
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