Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

sodium voltage-gated channel alpha subunit 3MIM:182391Ensembl:ENSG00000153253HGNC:HGNC:10590PA350052q24.3

GO terms in SCN3A

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0001518voltage-gated sodium channel complex
CCIBAGO:0005886plasma membrane
BPNASGO:0006814sodium ion transport
BPIBAGO:0019228neuronal action potential
BPIEAGO:0034765regulation of ion transmembrane transport
BPIBAGO:0035725sodium ion transmembrane transport
BPIEAGO:0035725sodium ion transmembrane transport
BPIBAGO:0086010membrane depolarization during action potential
MFIEAGO:0005244voltage-gated ion channel activity
MFIBAGO:0005248voltage-gated sodium channel activity
MFNASGO:0005248voltage-gated sodium channel activity
MFIBAGO:0005261cation channel activity

Gene expression in normal tissue: SCN3A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCN3A

DatabasePathway IDPathway Des.
kegghsa04742Taste transduction - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445095Interaction between L1 and Ankyrins
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5576892Phase 0 - rapid depolarisation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCN3A