SCN3A


Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
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GO terms in SCN3A


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0001518 voltage-gated sodium channel complex
CC IEA GO:0005737 cytoplasm
CC IBA GO:0005886 plasma membrane
BP NAS GO:0006814 sodium ion transport
BP IBA GO:0019228 neuronal action potential
BP IEA GO:0034765 regulation of ion transmembrane transport
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Gene expression in normal tissue: SCN3A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

ERK MAPK signaling1Protein stability and degradation1

Pathways in SCN3A


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Database
Pathway ID
Pathway Des.
kegg hsa04742 Taste transduction - Homo sapiens (human)
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-373760 L1CAM interactions
reactome R-HSA-397014 Muscle contraction
reactome R-HSA-422475 Axon guidance
reactome R-HSA-445095 Interaction between L1 and Ankyrins
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCN3A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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