CEACAM1


Summary: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010].

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GO terms in CEACAM1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ND GO:0003674 molecular_function
MF IPI GO:0003779 actin binding
MF IPI GO:0005515 protein binding
MF ISS GO:0005516 calmodulin binding
MF ISS GO:0015125 bile acid transmembrane transporter activity
MF IPI GO:0019900 kinase binding
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Gene expression in normal tissue: CEACAM1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in CEACAM1


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Database
Pathway ID
Pathway Des.
wikipathways WP2877 Vitamin D Receptor Pathway
reactome R-HSA-109582 Hemostasis
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-1566977 Fibronectin matrix formation
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CEACAM1

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Reference ID
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Cancer
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