CEACAM1
Summary: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:109770 Ensembl IDEnsembl:ENSG00000079385 HGNC IDHGNC:HGNC:1814 PHARMGKB IDPA26358 Map Location19q13.2 |
GO terms in CEACAM1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | ND | GO:0003674 | molecular_function |
MF | IPI | GO:0003779 | actin binding |
MF | IPI | GO:0005515 | protein binding |
MF | ISS | GO:0005516 | calmodulin binding |
MF | ISS | GO:0015125 | bile acid transmembrane transporter activity |
MF | IPI | GO:0019900 | kinase binding |
Gene expression in normal tissue: CEACAM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CEACAM1
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2877 | Vitamin D Receptor Pathway |
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-1474244 | Extracellular matrix organization |
reactome | R-HSA-1566977 | Fibronectin matrix formation |
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168256 | Immune System |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CEACAM1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |