Summary: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010].

carcinoembryonic antigen related cell adhesion molecule 1MIM:109770Ensembl:ENSG00000079385HGNC:HGNC:1814PA2635819q13.2

GO terms in CEACAM1

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0003779actin binding
MFIPIGO:0005515protein binding
MFISSGO:0005516calmodulin binding
MFISSGO:0015125bile acid transmembrane transporter activity
MFIPIGO:0019900kinase binding
MFIPIGO:0019903protein phosphatase binding
MFIPIGO:0031005filamin binding
MFIDAGO:0042802identical protein binding
MFIMPGO:0042803protein homodimerization activity
MFISSGO:0042803protein homodimerization activity
MFISSGO:0046983protein dimerization activity
MFIPIGO:1990782protein tyrosine kinase binding
BPISSGO:0001558regulation of cell growth
BPISSGO:0001568blood vessel development
BPIDAGO:0001915negative regulation of T cell mediated cytotoxicity
BPIMPGO:0002859negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
BPISSGO:0006469negative regulation of protein kinase activity
BPISSGO:0007155cell adhesion
BPISSGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPNASGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPNASGO:0007229integrin-mediated signaling pathway
BPISSGO:0010594regulation of endothelial cell migration
BPISSGO:0014066regulation of phosphatidylinositol 3-kinase signaling
BPISSGO:0015721bile acid and bile salt transport
BPNASGO:0016477cell migration
BPIDAGO:0030334regulation of cell migration
BPISSGO:0030853negative regulation of granulocyte differentiation
BPISSGO:0032692negative regulation of interleukin-1 production
BPISSGO:0032869cellular response to insulin stimulus
BPISSGO:0035726common myeloid progenitor cell proliferation
BPISSGO:0038016insulin receptor internalization
BPISSGO:0038158granulocyte colony-stimulating factor signaling pathway
BPISSGO:0042058regulation of epidermal growth factor receptor signaling pathway
BPISSGO:0043116negative regulation of vascular permeability
BPTASGO:0043312neutrophil degranulation
BPIDAGO:0043318negative regulation of cytotoxic T cell degranulation
BPIDAGO:0044319wound healing, spreading of cells
BPISSGO:0045601regulation of endothelial cell differentiation
BPISSGO:0045717negative regulation of fatty acid biosynthetic process
BPIDAGO:0050860negative regulation of T cell receptor signaling pathway
BPTASGO:0050900leukocyte migration
BPISSGO:0051055negative regulation of lipid biosynthetic process
BPISSGO:0060312regulation of blood vessel remodeling
BPISSGO:0070372regulation of ERK1 and ERK2 cascade
BPISSGO:0090331negative regulation of platelet aggregation
BPISSGO:0098742cell-cell adhesion via plasma-membrane adhesion molecules
BPISSGO:1901143insulin catabolic process
BPISSGO:1903385regulation of homophilic cell adhesion
BPISSGO:1903670regulation of sprouting angiogenesis
BPISSGO:2000346negative regulation of hepatocyte proliferation
BPISSGO:2001214positive regulation of vasculogenesis
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCIDAGO:0005911cell-cell junction
CCISSGO:0005912adherens junction
CCISSGO:0009925basal plasma membrane
CCIDAGO:0009986cell surface
CCISSGO:0009986cell surface
CCIDAGO:0016021integral component of membrane
CCIDAGO:0016324apical plasma membrane
CCISSGO:0016324apical plasma membrane
CCISSGO:0016328lateral plasma membrane
CCIDAGO:0030054cell junction
CCISSGO:0030054cell junction
CCIEAGO:0030658transport vesicle membrane
CCIEAGO:0031528microvillus membrane
CCTASGO:0035579specific granule membrane
CCIDAGO:0042101T cell receptor complex
CCHDAGO:0070062extracellular exosome
CCTASGO:0070821tertiary granule membrane

Gene expression in normal tissue: CEACAM1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CEACAM1

DatabasePathway IDPathway Des.
wikipathwaysWP2877Vitamin D Receptor Pathway
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566977Fibronectin matrix formation
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CEACAM1