SDCBP
Summary: The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| syndecan binding protein | MIM:602217 | Ensembl:ENSG00000137575 | HGNC:HGNC:10662 | PA35592 | 8q12.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in SDCBP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005109 | frizzled binding |
| MF | ISS | GO:0005137 | interleukin-5 receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | NAS | GO:0008093 | cytoskeletal adaptor activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0045545 | syndecan binding |
| MF | IPI | GO:0045545 | syndecan binding |
| MF | NAS | GO:0045545 | syndecan binding |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | NAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | NAS | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005895 | interleukin-5 receptor complex |
| CC | NAS | GO:0005912 | adherens junction |
| CC | IEA | GO:0005925 | focal adhesion |
| CC | NAS | GO:0016020 | membrane |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | TAS | GO:0035578 | azurophil granule lumen |
| CC | IEA | GO:0042470 | melanosome |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
| CC | HDA | GO:0072562 | blood microparticle |
| CC | HDA | GO:1903561 | extracellular vesicle |
| BP | IMP | GO:0002091 | negative regulation of receptor internalization |
| BP | NAS | GO:0006612 | protein targeting to membrane |
| BP | NAS | GO:0006930 | substrate-dependent cell migration, cell extension |
| BP | NAS | GO:0007268 | chemical synaptic transmission |
| BP | IMP | GO:0007346 | regulation of mitotic cell cycle |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | IBA | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IMP | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IBA | GO:0023051 | regulation of signaling |
| BP | NAS | GO:0030036 | actin cytoskeleton organization |
| BP | IMP | GO:0030307 | positive regulation of cell growth |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IBA | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | NAS | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0042327 | positive regulation of phosphorylation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IC | GO:0046330 | positive regulation of JNK cascade |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IMP | GO:1903543 | positive regulation of exosomal secretion |
| BP | IMP | GO:1903553 | positive regulation of extracellular exosome assembly |
Gene expression in normal tissue: SDCBP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SDCBP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP2858 | Ectoderm Differentiation |
| pid | il5_pathway | IL5-mediated signaling events |
| pid | syndecan_1_pathway | Syndecan-1-mediated signaling events |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_TCR | TCR |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-447043 | Neurofascin interactions |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SDCBP
CLASSFICATION
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