SDCBP
Summary: The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602217 Ensembl IDEnsembl:ENSG00000137575 HGNC IDHGNC:HGNC:10662 PHARMGKB IDPA35592 Map Location8q12.1 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in SDCBP
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005109 | frizzled binding |
| MF | ISS | GO:0005137 | interleukin-5 receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | NAS | GO:0008093 | cytoskeletal adaptor activity |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: SDCBP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SDCBP
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP2858 | Ectoderm Differentiation |
| pid | il5_pathway | IL5-mediated signaling events |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SDCBP
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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